Free MCCQE Practice Test Questions 2026

A 70-year-old woman had a total abdominal hysterectomy with bilateral salpingooophorectomy 2 days ago. On examination today, her vital signs are as follows: She has been immobile since her operation. She is fatigued but is tolerating a full diet. Which one of the following is the most likely cause of this patient's fever?

A. Septic pelvic thrombophlebitis.

B. Pulmonary embolism.

C. Wound infection.

D. Bowel trauma during the operation.

E. Atelectasis

A 39-year-old woman, gravida 2, para 1, aborta 0, presents with concerns that a friend has recently suffered from postpartum psychosis. She wonders if she is likely to suffer this disorder following delivery of her 2nd child. Which one of the following is most likely to increase your patient's risk?

A. Advanced maternal age

B. Being a multigravida

C. A family history of bipolar disorder

D. A history of panic disorder

A 26-year-old man presents to your office with fever, chills, and malaise. Aside from an episode of dysuria 8 weeks ago, which spontaneously resolved, he has been healthy. On examination, his left wrist and right ankle are tender. There is a cluster of vesiculopustular lesions on his right hand. Which one of the following is the most likely diagnosis?

A. Primary HIV infection syndrome

B. Disseminated gonococcemia

C. Reactive arthritis

D. Rheumatoid arthritis

E. Varicella

A 37-year-old man comes to the office for follow-up of his opioid use disorder. He receives opioid agonist treatment, including some take-home doses. At this follow-up visit, he reports some nonprescription opioid use since his last visit. Which one of the following is the best next step?

A. Taper the dosage of the opioid agonist

B. Discontinue take-home doses

C. Increase the frequency of follow-up visits

D. Prescribe a cannabinoid

E. Slowly taper and discontinue the opioid agonist

A 12-year-old girl presents to your office in late November with an exacerbation of asthma which has been well controlled since her diagnosis at age 5. The family has had cats for 3 years. Last June, they moved to a basement apartment. Which one of the following is the most likely cause of her asthma exacerbation?

A. Fungal infection

B. Cat allergy

C. Mold allergy

D. Pollen allergy

E. Cold intolerance

A 15-year-old boy is brought to the office by his father because he is having headaches. When alone, the boy appears withdrawn and admits to suicidal ideation. He shares that he is gay but does not want to tell his parents. He says that he faked the headaches so that one of his parents would make an appointment for him. Which one of the following is the best next step?

A. Start an antidepressant medication.

B. Encourage the patient to disclose his sexual orientation to his parents.

C. Suggest that the patient join a group at school for peer support.

D. Refer the patient for an immediate mental health assessment.

39-year-old woman comes to the office for a periodic health examination. She reports that her father had a recent diagnosis of breast cancer (at age 62 years) and that a paternal aunt had ovarian cancer in her early 40s. The results of mammography are normal. Which one of the following is the most appropriate recommendation for this patient?

A. Prophylactic tamoxifen therapy.

B. Genetic screening.

C. Random fine-needle sampling of the breasts.

D. Annual mammography starting at age 50 years.

E. Bilateral mastectomy.

A 34-year-old woman, gravida 2, para 1, aborta 0, presents to the labor and delivery ward at 32 weeks' gestation with a 24-hour history of worsening frontal headache, photophobia, and neck stiffness. Vitals: BP: 121/78 mm Hg HR: 90 bpm Temp: 38°C Neuro exam reveals a 2-beat ankle clonus. Tone and power are otherwise normal. No localizing signs or papilledema. Abdomen is soft, fetus is cephalic. Which one of the following is the best next investigation?

A. Computed tomography of the head

B. Lumbar puncture

C. Fetal ultrasonography

D. Amniocentesis with culture

E. Urine protein to creatinine ratio

A 59-year-old woman comes to the office because her 48-year-old sister was recently diagnosed with cervical cancer. Your patient thinks her mother may have also had cervical cancer. A Papanicolaou (Pap) test performed 16 months ago had normal results, as did all previous Pap tests. Which one of the following is the best next step?

A. Offer a repeat Pap test now.

B. Offer annual Pap testing for the next 5 years.

C. Offer a repeat Pap test 3 years from the previous one.

D. Arrange for human papillomavirus testing.

E. Arrange for colposcopy.

You are conducting a virtual appointment by voice-only call with a 68-year-old man regarding back pain. When he answers, you ask for him by name and identify yourself and the clinic from which you are calling. Which one of the following is the best next step?

A. Establish the reason for the virtual care visit.

B. Confirm the name of the patient's primary care provider.

C. Ask for additional confirmation of the patient's identity.

A 70-year-old hypertensive woman with a history of congestive heart failure (CHF) secondary to left ventricular dysfunction presents to your office with a persistent dry hacking cough. She claims it began when she was started on ramipril. Which one of the following medications would be most appropriate to replace ramipril, to ensure that the risk of morbidity associated with CHF remains low?

A. Angiotensin II receptor blocker

B. Calcium channel blocker

C. Nitrates

D. Alpha-blocker

E. Cox-2 inhibitor

A 29-year-old man comes to the office for an initial visit. He is being treated for schizophrenia and epilepsy. He has a 20 pack-year history of smoking. His medications are carbamazepine, clozapine, and quetiapine. In the past year, he has gained a considerable amount of weight. Asidefrom a BMI of 32, the results of his physical examination are unremarkable. Which one of the following conditions should he be investigated for?

A. Chronic obstructive pulmonary disease

B. Cushing disease

C. Sleep apnea

D. Type 2 diabetes

E. Acromegaly